論文：乳児栄養研究
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発表者 Keiji Takahashi1)2), Keiko Tanaka1)3), Yoshitaka Nakamura2), Hitomi Okubo1), Satoshi Sasaki4), Masashi Arakawa5) and Yoshihiro Miyake1)3)
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Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine
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Food Science & Technology Research Laboratories, R&D Division, Meiji CO., Ltd.
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Epidemiology and Medical Statistics Unit, Translational Reserach Center, Ehime University Hospital
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Department of Social and Preventive Epidemiology, Graduate School of Medicine, The University of Tokyo
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Health Tourism Research Fields, Graduate School of Tourism Sciences, University of the Ryukyus
雑誌名 NUTRITIONAL NEUROSCIENCE https://www.tandfonline.com/doi/full/10.1080/1028415X.2019.1676971（2019）
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発表者 Yoshitaka Nakamura1), Michiko Fukushima2), Seiko Hoshi3), Amares Chatt4) and Takashi Sakata2)
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Food Science & Technology Research Laboratories, Meiji Co., Ltd.
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Ishinomaki Senshu University
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Shokei Gakuin University
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Department of Chemistry, Dalhousie University
雑誌名 JOURNAL OF NUTRITIONAL SCIENCE (2019),vol.8,e24,page1of8（2019）
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発表者 Shinji Jinno, Kae Yamazaki, Yoshitaka Nakamura and Toshi Kinouchi
雑誌名 Bioscience,Biotechnology,and Biochemistry https://doi.org/10.1080/09168451.2019.1689096（2019）
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発表者 Katsunori Tanaka1)2), Yoshitaka Nakamura3), Masaki Terahara3), Takahide Yanagi1), Sayuri Nakahara1), Ouki Furukawa1), Hidemi Tsutsui1), Ryo Inoue4), Takamitsu Tukahara5) and Shigeki Koshida6)
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Department of Pediatrics, shiga University of Medical Science
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Department of Pediatrics, National Hospital Organization Higashi-Ohmi General Medical Center
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Food Science & Technology Research Laboratiries, Meiji Co.,Ltd.
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Department of Agricultural and Life Sciences, Kyoto Prefectural University
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Kyoto Institute of Nutrition & Pathology
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Department of Community Perinatal Medicine, Shiga University of Medical Science
雑誌名 Nutrients 2019,11(4),839;doi:10.3390/nu11040839（2019）
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発表者 Satsuki Totsu, Masaki Terahara, Satoshi Kusuda
雑誌名 BMJ Peadiatrics Open 2018 Apr 17;2(1):e000256doi:10.1136/bmjpo-2018-000256（2018）
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発表者 叶内茜、倉持清美、中村吉孝、三輪香織、南道子
雑誌名 保育と保健 23(2):46-49（2017）
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発表者 神野慎治、利光孝之、中村吉孝、久保田隆之、井越有香、小澤直子、鈴木修一、中野泰至、森田慶紀、有馬孝恭、山出史也、河野陽一、増田健太郎、下条直樹
雑誌名 Nutrients 9(3)（2017）
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発表者 Katsunori Tanaka, Takamitsu Tsukahara, Takahide Yanagi, Sayuri Nakahara, Ouki Furukawa, Hidemi Tsutsui, Shigeki Koshida 雑誌名 Nutrients 9(3)（2017） -
発表者 叶内茜、倉持清美、中村吉孝、三輪香織、南道子
雑誌名 保育と保健 22(1):41-44（2016）
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発表者 叶内茜、倉持清美、中村吉孝、井川愛、三輪香織、伊藤裕之、南道子
雑誌名 保育と保健 21(1):46-49（2015）
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発表者 神野慎治
雑誌名 ミルクサイエンス 64(1):35-42（2015）
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発表者 内海明美、中村吉孝、石崎晶子、Kayo Nomura, 井川愛、三輪香織、園田菜摘、金子佳代子、向井美惠 、弘中祥司
雑誌名 Pediatric Dental Journal 25(3):55-63（2015）
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発表者 Qinwen Du, Hiroshi Hosoda, Takashi Umekawa, 木ノ内俊、豊田なつ来、Mikiya Miyazato, Kenji Kangawa, Tomoaki Ikeda
雑誌名 Peptides 70:23-31（2015）
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発表者 神野慎治、中村吉孝、長田昌士、高橋毅
雑誌名 Bioscience, Biotechnology, and Biochemistry 78(5):861-866（2014）
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発表者 矢島昌子、矢島高二、桑田有
雑誌名 腸内細菌学雑誌20,19-24（2006）
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発表者 Masako Yajima, Takaji Yajima, Tamotsu Kuwata
雑誌名 Biomedical Research 26(6)249-255（2005）
要約 Intraperitoneal injection of lactoferrin ameliorates severe albumin extravasation and neutrophilia in LPS-induced inflammation in neonatal rats
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発表者 菅野貴浩、米久保明得
雑誌名 小児保健研究64(4)594-601（2005）
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発表者 菅野貴浩、米久保明得
雑誌名 小児保健研究64(4)585-593（2005）
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発表者 木ノ内俊
雑誌名 周産期医学35(増刊号）370-373（2005）
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発表者 高橋毅
雑誌名 小児内科37(5)641-643（2005）
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発表者 Y.Nakamura, S.Nosaka, M.Suzuki, S.Nagafuchi, T.Takahashi, T.Yajima, N.Takenouchi-Ohkubo, T.Iwase, I.Moro
雑誌名 Clinical & Experimental Immunology 137(1)52-58（2004）
要約 Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice
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発表者 金子哲夫、山脇奈見子
雑誌名 Biomedical Research on Trace Elements 15(3)235-242（2004）
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発表者 金子哲夫
雑誌名 日本臨床栄養学会雑誌25(4)288-292（2004）
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発表者 中村吉孝、野坂晶子、鈴木美沙、高橋毅、矢島高二、茂呂周
雑誌名 消化器と免疫40,38-40（2003）
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発表者 Toshi Kinouchi, Takaji Yajima
雑誌名 Biology of the Intestine in Growing Animals 203-220（2002）
要約 Roles of milk-borne components in the development of pancreactic enzymes during the suckling period
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発表者 Toshi Kinouchi, Takaji Yajima
雑誌名 The Bio-defensive Function of Dairy Foods 77-88（2002）
要約 Biological function of hormones in milk
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発表者 Shinya Nagafuchi, Mamoru Totsuka, Satoshi Hachimura, Masao Goto, Takeshi Takahashi, Takaji Yajima, Tamotsu Kuwata, Shuichi Kaminogawa
雑誌名 Cytotechnology 40,49-58（2002）
要約 Dietary nucleotides increase the mucosal IgA response and the secretion of transforming growth factor β from intestinal epithelial cells in mice
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発表者 高橋毅
雑誌名 Food Style21 5(3)56-60（2001）
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発表者 T.Kinouchi, K.Koizumi, T.Kuwata, T.Yajima
雑誌名 Journal of Pediatric Gastroenterology and Nutrition 30(5)515-521（2000）
要約 Milk-Borne Insulin With Trypsin Inhibitor in Milk Induces Pancreatic Amylase Development at the Onset of Weaning in Rats
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発表者 M.Yajima, M.Nakayama, S.Hatano, K.Yamazaki, Y.Aoyama, T.Yajima, T. Kuwata
雑誌名 Journal of Pediatric Gastroenterology and Nutrition 33(5)592-601（2001）
要約 Bacterial Translocation in Neonatal Rats: The Relation Between Intestinal Flora, Translocated Bacteria, and Influence of Milk
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発表者 Tetsuo Kaneko, Yuka Teresawa, Yukiko Senno, Masashi Nagata,Tamotsu Kuwata
雑誌名 International Archives of Allergy and Immunology 121,317-323（2000）
（出版元S.kargerAG,Basel）要約 Enhancing Effect of Dietary Oil Emulsions on Immune Responses to Protein Antigens Fed to Mice
食餌性乳化油脂はマウスの摂取タンパク質抗原に対する免疫応答を増強する（要旨）
Enhancing Effect of Dietary Oil Emulsions on Immune Responses to Protein Antigens Fed to Mice
Tetsuo Kaneko, Yuka Teresawa, Yukiko Senno, Masashi Nagata,Tamotsu KuwataInternational Archives of Allergy and Immunology 121,317-323（2000）（出版元 S.kargerAG,Basel）
要旨
Abstract: Repeated intragastric administrations of β-lactoglobulin(β-Lg) with emulsified soybean oil elicited an antigen-specific, systemic humoral immune response in different strains of mice. The antibody response was enhanced as the dose of oil was increased and the particle size of emulsions was decreased. Feeding of aqueous β-Lg could induce the antibody response only when emulsified oil was fed almost simultaneously. However, the emulsion-driven humoral immune response was not observed when mice were treated with anti-CD40 ligand antibody or in athymic mice. It is likely that the intestinal coexistence of emulsified oil with dietary antigens modulates the immune system to crucially support B cell response. A practical application of the present results to the prevention of cow's milk protein sensitization is infants proposed.
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発表者 Sinya Nagafuchi, Mamoru Totsuka, Satoshi Hachimura, Masao Goto, Takeshi Takahashi, Takaji Yajima, Tamotsu Kuwata, Shuichi Kaminogawa
雑誌名 Bioscience Biotechnology Biochemistry 64(7)1459-1465（2000）
要約 Dietary Nucleotides Increase the Proportion of a TCRγδ+Subset of Intraepithelial Lymphocytes (IEL) and IL-7 Production by Intestinal Epithelial Cells (IEC); Implications for Modification of Cellular and Molecular Cross-talk between IEL and IEC by Dietary Nucleotides
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発表者 Sinya Nagafuchi, Satoshi Hachimura, Mamoru Totsuka, Takeshi Takahashi, Masao Goto, Takaji Yajima, Tamotsu Kuwata, Sonoko Habu, Shuichi Kaminogawa
雑誌名 International Archives of Allergy and Immunology 122,33-41（2000）
（出版元S.kargerAG,Basel）要約 Dietary Nucleotides Can Up-Regulate Antigen-Specific Th1 Immune Responses and Suppress Antigen-Specific IgE Responses in Mice
ヌクレオチドの経口摂取は、マウスの抗原特異的なTh1免疫応答を促進し、抗原特異的なIgE産生を抑制する （要旨）
Dietary Nucleotides Can Up-Regulate Antigen-Specific Th1 Immune Responses and Suppress Antigen-Specific IgE Responses in Mice Sinya Nagafuchi, Satoshi Hachimura, Mamoru Totsuka, Takeshi Takahashi, Masao Goto, Takaji Yajima, Tamotsu Kuwata, Sonoko Habu, Shuichi Kaminogawa International Archives of Allergy and Immunology 122,33-41（2000） （出版元 S.kargerAG,Basel）
要旨
Abstract
Background: It has been reported that dietary nucleotides enhance T helper cell activities. In this study, we have determined the effects of dietary nucleotides on antigen-specific Th1 and Th2 responses and IgE responses. Methods: Ovalbumin (OVA) -specific T cell receptor (TCR) transgenic (OVA-TCR Tg) mice, 3 weeks old, were fed a nucleotide-free diet (NT(-) diet) or the NT(-) diet supplemented with dietary nucleotides (NT(+) diet) for 4 weeks. Cytokine production by spleen cells and macrophages obtained from these mice was measured in vitro. BALB/c mice, 3 weeks old, immunized intraperitoneally with OVA adsorbed onto alum, were fed the NT(-) diet or the NT(+) diet for 4 weeks. Serum levels of antigen-specific antibodies in the BALB/c mice were determined by ELISA. Results: The level of production of antigen-specific interferon-γ by spleen cells was significantly higher in the OVA-TCR Tg mice fed the NT(+) diet than in the control mice. The levels of secretion of bioactive IL-12 by spleen cells and peritoneal macrophages were also significantly increased in the NT(+) diet group. The serum OVA-specific IgE level was significantly decreased in BALB/c mice fed the NT(+) diet compared with those fed the NT(-) diet. Conclusion: These results show that dietary nucleotides up-regulate the antigen-specific Th1 immune response through the enhancement of IL-12 production and suppress the antigen-specific IgE response.
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発表者 金子哲夫
雑誌名 日本臨床栄養学会雑誌21(3, 4)13-17（2000）
