論文:乳児栄養研究

  • 明治の乳児用ミルク開発(2023)
    発表者

    中村吉孝

    雑誌名

    ミルクサイエンス Vol.72, No.2, 2023, p92-93(2023)

  • Direct effect of 2-palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal-derived astrocytes(2022)
    発表者

    Misato Tsuboi1)2), Yoshitaka Nakamura1), Hiroshi Sakuma2)3)
    1)Food Microbiology and Function Research Laboratories, R&D Division, Meiji Co., Ltd.
    2)Department of Pediatric Neurology, Niigata University Graduate School of Medical and Dental Sciences
    3)Department of Brain and Neuroscience, Tokyo Metropolitan Institute of Medical Science

    雑誌名

    FEBS Open Bio 13(2023)1320-1332(2022)

  • Highest concentration of breast-milk-derived exosomes in colostrum(2022)
    発表者

    Ohta M1), Koshida S2), Jimbo I3), Oda M3)4), Inoue R3)4), Tsukahara T5), Terahara M6), Nakamura Y7), Maruo Y1)
    1)Department of Pediatrics, Shiga University of Medical Science.
    2)Perinatal Center, Shiga University of Medical Science.
    3)Laboratory of Animal Science, Department of Agricultural and Life Sciences, Kyoto Prefectural University.
    4)Laboratory of Animal Science, Department of Applied Biological Sciences, Faculty of Agriculture, Setsunan University - Hirakata Campus.
    5)Kyoto Institute of Nutrition & Pathology.
    6)R&D Management Department, Meiji Co., Ltd.
    7)Food Microbiology and Function Research Laboratories, Meiji Co., Ltd.

    雑誌名

    Pediatrics International Vol. 64 (1), e15346(2022)

  • Maternal Consumption of Dairy Products during Pregnancy Is Associated with Decreased Risk of Emotional Problems in 5-Year-olds: The Kyushu Okinawa Maternal and Child Health Study(2022)
    発表者

    Nguyen M.Q1), Miyake Y2)3)4)5), Tanaka K2)3)4)5), Hasuo S1), Takahashi K6), Nakamura Y1), Okubo H2)7)8), Sasaki S9), and Arakawa M10)11)
    1)Food Microbiology and Function Research Laboratories, R&D Division, Meiji Co., Ltd., Tokyo 192-0919, Japan.
    2)Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Matsuyama 791-0295, Japan.
    3)Integrated Medical and Agricultural School of Public Health, Ehime University, Matsuyama 791-0295, Japan.
    4)Research Promotion Unit, Translational Research Center, Ehime University Hospital, Matsuyama 791-0295, Japan.
    5)Center for Data Science, Ehime University, Matsuyama 790-8577, Japan.
    6)Food Science and Technology Research Laboratories, R&D Division, Meiji Co., Ltd., Tokyo 192-0919, Japan.
    7)Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Osaka 305-8506, Japan.
    8)Japan Society for the Promotion of Science, Tokyo 102-0083, Japan.
    9)Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo 192-0397, Japan.
    10)Wellness Research Fields, Faculty of Global and Regional Studies, University of the Ryukyus, Tomigusuku 903-0213, Japan.
    11)The Department of Cross Cultural Studies, Osaka University of Tourism, Tomigusuku 590-0493, Japan.

    雑誌名

    Nutrients Vol.14 (22), 4713(2022)

  • Effect of Bifidobacterium Bifidum Administration on Term Infants at 1 year of Age:An Open-Label Randomized Control Trial.(2022)
    発表者

    Satsuki Totsu, Ayako Nishiyama, Masaki Terahara, Masaki Wada, and Satoshi Kusuda

    雑誌名

    British Journal of Gastroenterology Vol.4 (1), 229-234(2022)

  • Chronological changes of serum exosome in preterm infants: A prospective study(2021)
    発表者

    Motoki Ohta, Shigeki Koshida, Itsuki Jimbo, Machi Oda, Ryo Inoue, Takamitsu Tsukahara, Masaki Terahara, Takahide Yanagi, Sayuri Nakahara, Masami Shibata, Hidemi Tsutsui, Daisuke Yoshida, Ouki Furukawa, Yoshihiro Maruo

    雑誌名

    Pediatric International doi:10.1111/PED.14933(2021)

  • Effects of the intake of non-live Bifidobacterium bifidum on the faecal IgA of full-term infants: a double-blind, randomised, placebo-controlled study(2021)
    発表者

    Masaki Terahara, Yoshitaka Nakamura, Misato Tsuboi, Shinji Jinno, Takamitsu Tsukahara, Takao Miyake, Naoki Shimojo

    雑誌名

    Bioscience of Microbiota, Food and Health 40 (4), 196-203(2021)

  • Daily protein and energy intakes of infants fed a commercial infant formula with a reduced protein concentration of 2.2 g/100 kcal: an impact of feeding interval on energy intake.(2020)
    発表者

    Shinji Jinno1), Kae Yamazaki1), Yoshitaka Nakamura1), Toshi Kinouchi2)

    1. 1)
      Nutrition Research Department, Food Microbiology and Function Research Laboratories, R&D Division, Meiji Co., Ltd.
    2. 2)
      Marketing Solution Department, Marketing & Development Management Division, Meiji Co., Ltd.
    雑誌名

    Bioscience,Biotechnology,and Biochemistry(2020)
    https://doi.org/10.1080/09168451.2020.1722609

  • Calcium intake during pregnancy is associated with decreased risk of emotional and hyperactivity problems in five-year-old Japanese children(2019)
    発表者

    Keiji Takahashi1)2), Keiko Tanaka1)3), Yoshitaka Nakamura2), Hitomi Okubo1), Satoshi Sasaki4), Masashi Arakawa5) and Yoshihiro Miyake1)3)

    1. 1)
      Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine
    2. 2)
      Food Science & Technology Research Laboratories, R&D Division, Meiji CO., Ltd.
    3. 3)
      Epidemiology and Medical Statistics Unit, Translational Reserach Center, Ehime University Hospital
    4. 4)
      Department of Social and Preventive Epidemiology, Graduate School of Medicine, The University of Tokyo
    5. 5)
      Health Tourism Research Fields, Graduate School of Tourism Sciences, University of the Ryukyus
    雑誌名

    NUTRITIONAL NEUROSCIENCE https://www.tandfonline.com/doi/full/10.1080/1028415X.2019.1676971(2019)

  • Estimation of daily selenium intake by 3- to 5-year-old Japanese children based on selenium excretion in 24-h urine samples(2019)
    発表者

    Yoshitaka Nakamura1), Michiko Fukushima2), Seiko Hoshi3), Amares Chatt4) and Takashi Sakata2)

    1. 1)
      Food Science & Technology Research Laboratories, Meiji Co., Ltd.
    2. 2)
      Ishinomaki Senshu University
    3. 3)
      Shokei Gakuin University
    4. 4)
      Department of Chemistry, Dalhousie University
    雑誌名

    JOURNAL OF NUTRITIONAL SCIENCE (2019),vol.8,e24,page1of8(2019)

  • Growth of term infants fed a commercial infant formula with a protein content of 2.2 g/100 kcal: an observational follow-up study(2019)
    発表者

    Shinji Jinno, Kae Yamazaki, Yoshitaka Nakamura and Toshi Kinouchi

    雑誌名

    Bioscience,Biotechnology,and Biochemistry https://doi.org/10.1080/09168451.2019.1689096(2019)

  • Poor Bifidobacterial Colonization Is Associated with Late Provision of Colostrum and Improved with Probiotic Supplementation in Low Birth Weight Infants(2019)
    発表者

    Katsunori Tanaka1)2), Yoshitaka Nakamura3), Masaki Terahara3), Takahide Yanagi1), Sayuri Nakahara1), Ouki Furukawa1), Hidemi Tsutsui1), Ryo Inoue4), Takamitsu Tukahara5) and Shigeki Koshida6)

    1. 1)
      Department of Pediatrics, shiga University of Medical Science
    2. 2)
      Department of Pediatrics, National Hospital Organization Higashi-Ohmi General Medical Center
    3. 3)
      Food Science & Technology Research Laboratiries, Meiji Co.,Ltd.
    4. 4)
      Department of Agricultural and Life Sciences, Kyoto Prefectural University
    5. 5)
      Kyoto Institute of Nutrition & Pathology
    6. 6)
      Department of Community Perinatal Medicine, Shiga University of Medical Science
    雑誌名

    Nutrients 2019,11(4),839;doi:10.3390/nu11040839(2019)

  • Probiotics and the development of very-low-birth-weight infants: Follow up study of a randomized trial(2018)
    発表者

    Satsuki Totsu, Masaki Terahara, Satoshi Kusuda

    雑誌名

    BMJ Peadiatrics Open 2018 Apr 17;2(1):e000256doi:10.1136/bmjpo-2018-000256(2018)

  • 新生児を対象とするプロバイオティクス開発への挑戦(2017)
    発表者

    寺原正樹

    雑誌名

    Milk Science Vol.66, No. 3, 247-253(2017)

  • 3歳児を対象とした3ヶ月間の咀嚼教育支援による教育効果の持続性―介入後3・22ヶ月の調査から―(2017)
    発表者

    叶内茜、倉持清美、中村吉孝、三輪香織、南道子

    雑誌名

    保育と保健 23(2):46-49(2017)

  • Maternal preboitic ingestion increased fecal bifidobacteria in pregnant women, but not in their neonates aged 1 month(2017)
    発表者

    神野慎治、利光孝之、中村吉孝、久保田隆之、井越有香、小澤直子、鈴木修一、中野泰至、森田慶紀、有馬孝恭、山出史也、河野陽一、増田健太郎、下条直樹

    雑誌名

    Nutrients 9(3)(2017)

  • Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study(2017)
    発表者 Katsunori Tanaka, Takamitsu Tsukahara, Takahide Yanagi, Sayuri Nakahara, Ouki Furukawa, Hidemi Tsutsui, Shigeki Koshida
    雑誌名 Nutrients 9(3)(2017)

  • 保護者への介入内容がもたらす幼児の咀嚼力向上への効果(2016)
    発表者

    叶内茜、倉持清美、中村吉孝、三輪香織、南道子

    雑誌名

    保育と保健 22(1):41-44(2016)

  • 噛みしめる幼児食をツールとした咀嚼教育プログラムの効果(2015)
    発表者

    叶内茜、倉持清美、中村吉孝、井川愛、三輪香織、伊藤裕之、南道子

    雑誌名

    保育と保健 21(1):46-49(2015)

  • 乳児用ミルクの栄養設計に不可欠な乳児発育評価(2015)
    発表者

    神野慎治

    雑誌名

    ミルクサイエンス 64(1):35-42(2015)

  • Design of safe foods that induce mastication in very young children(2015)
    発表者

    内海明美、中村吉孝、石崎晶子、Kayo Nomura, 井川愛、三輪香織、園田菜摘、金子佳代子、向井美惠 、弘中祥司

    雑誌名

    Pediatric Dental Journal 25(3):55-63(2015)

  • Postnatal weight gain induced by overfeeding pups and maternal high-fat diet during the lactation period modulates glucose metabolism and the production of pancreatic and gastrointestinal peptides(2015)
    発表者

    Qinwen Du, Hiroshi Hosoda, Takashi Umekawa, 木ノ内俊、豊田なつ来、Mikiya Miyazato, Kenji Kangawa, Tomoaki Ikeda

    雑誌名

    Peptides 70:23-31(2015)

  • 1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice(2014)
    発表者

    神野慎治、中村吉孝、長田昌士、高橋毅

    雑誌名

    Bioscience, Biotechnology, and Biochemistry 78(5):861-866(2014)

  • 哺乳期ラットのバクテリアルトランスロケーション:腹腔滲出性多形核白血球の貪食作用に及ぼす影響(2006)
    発表者

    矢島昌子、矢島高二、桑田有

    雑誌名

    腸内細菌学雑誌20,19-24(2006)

  • LPS誘導性炎症時に認められる滲出性アルブミン貯留と好中球増多はラクトフェリンの腹腔投与により予防される:乳児期ラットにおける検討(2005)
    発表者

    Masako Yajima, Takaji Yajima, Tamotsu Kuwata

    雑誌名

    Biomedical Research 26(6)249-255(2005)

    要約

    Intraperitoneal injection of lactoferrin ameliorates severe albumin extravasation and neutrophilia in LPS-induced inflammation in neonatal rats

  • 栄養法別にみた乳児の発育、哺乳量、便性ならびに罹病傾向に関する調査成績(第10報)(2005)
    発表者

    菅野貴浩、米久保明得

    雑誌名

    小児保健研究64(4)594-601(2005)

  • 栄養法別にみた乳児の発育、哺乳量、便性ならびに罹病傾向に関する調査成績(第9報)(2005)
    発表者

    菅野貴浩、米久保明得

    雑誌名

    小児保健研究64(4)585-593(2005)

  • 低出生体重児用ミルクの蛋白質栄養の設計(2005)
    発表者

    木ノ内俊

    雑誌名

    周産期医学35(増刊号)370-373(2005)

  • 母乳と人工乳の違いで免疫能に違いはでるのか?(2005)
    発表者

    高橋毅

    雑誌名

    小児内科37(5)641-643(2005)

  • フラクトオリゴ糖の投与は哺乳期マウスの腸管における免疫グロブリンAの産生と分泌成分の発現を増加させる(2004)
    発表者

    Y.Nakamura, S.Nosaka, M.Suzuki, S.Nagafuchi, T.Takahashi, T.Yajima, N.Takenouchi-Ohkubo, T.Iwase, I.Moro

    雑誌名

    Clinical & Experimental Immunology 137(1)52-58(2004)

    要約

    Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice

  • 微量元素と母乳および調製粉乳(2004)
    発表者

    金子哲夫、山脇奈見子

    雑誌名

    Biomedical Research on Trace Elements 15(3)235-242(2004)

  • 食物アレルギーの食品開発(2004)
    発表者

    金子哲夫

    雑誌名

    日本臨床栄養学会雑誌25(4)288-292(2004)

  • 哺乳期からのフラクトオリゴ糖の経口摂取が腸管IgAの分泌ならびに分泌成分(polymeric immunoglobulin receptor)発現に与える影響(2003)
    発表者

    中村吉孝、野坂晶子、鈴木美沙、高橋毅、矢島高二、茂呂周

    雑誌名

    消化器と免疫40,38-40(2003)

  • 乳仔期の膵消化機能発達における母乳中成分の役割(2002)
    発表者

    Toshi Kinouchi, Takaji Yajima

    雑誌名

    Biology of the Intestine in Growing Animals 203-220(2002)

    要約

    Roles of milk-borne components in the development of pancreactic enzymes during the suckling period

  • 母乳中ホルモンの生理機能(2002)
    発表者

    Toshi Kinouchi, Takaji Yajima

    雑誌名

    The Bio-defensive Function of Dairy Foods 77-88(2002)

    要約

    Biological function of hormones in milk

  • ヌクレオチドの経口摂取は、マウスの腸管IgA産生および小腸上皮細胞のTGF-β産生を促進する(2002)
    発表者

    Shinya Nagafuchi, Mamoru Totsuka, Satoshi Hachimura, Masao Goto, Takeshi Takahashi, Takaji Yajima, Tamotsu Kuwata, Shuichi Kaminogawa

    雑誌名

    Cytotechnology 40,49-58(2002)

    要約

    Dietary nucleotides increase the mucosal IgA response and the secretion of transforming growth factor β from intestinal epithelial cells in mice

  • 核酸関連物質の抗アレルギー作用と応用(2001)
    発表者

    高橋毅

    雑誌名

    Food Style21 5(3)56-60(2001)

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  • 乳中のインスリンおよびトリプシンインヒビターによる離乳初期ラットの膵アミラーゼ増加の誘導(2000)
    発表者

    T.Kinouchi, K.Koizumi, T.Kuwata, T.Yajima

    雑誌名

    Journal of Pediatric Gastroenterology and Nutrition 30(5)515-521(2000)

    要約

    Milk-Borne Insulin With Trypsin Inhibitor in Milk Induces Pancreatic Amylase Development at the Onset of Weaning in Rats

  • 哺乳期ラットのバクテリアルトランスロケーション:腸内菌叢構成とバクテリアルトランスロケーションを起こした細菌の関連性、それらに及ぼす人工乳と母乳の影響(2001)
    発表者

    M.Yajima, M.Nakayama, S.Hatano, K.Yamazaki, Y.Aoyama, T.Yajima, T. Kuwata

    雑誌名

    Journal of Pediatric Gastroenterology and Nutrition 33(5)592-601(2001)

    要約

    Bacterial Translocation in Neonatal Rats: The Relation Between Intestinal Flora, Translocated Bacteria, and Influence of Milk

  • 食餌性乳化油脂はマウスの摂取タンパク質抗原に対する免疫応答を増強する(2000)
    発表者

    Tetsuo Kaneko, Yuka Teresawa, Yukiko Senno, Masashi Nagata,Tamotsu Kuwata

    雑誌名

    International Archives of Allergy and Immunology 121,317-323(2000)
    (出版元S.kargerAG,Basel)

    要約

    Enhancing Effect of Dietary Oil Emulsions on Immune Responses to Protein Antigens Fed to Mice


    食餌性乳化油脂はマウスの摂取タンパク質抗原に対する免疫応答を増強する(要旨)

    Enhancing Effect of Dietary Oil Emulsions on Immune Responses to Protein Antigens Fed to Mice

    Tetsuo Kaneko, Yuka Teresawa, Yukiko Senno, Masashi Nagata,Tamotsu KuwataInternational Archives of Allergy and Immunology 121,317-323(2000)(出版元 S.kargerAG,Basel)

    要旨

    Abstract: Repeated intragastric administrations of β-lactoglobulin(β-Lg) with emulsified soybean oil elicited an antigen-specific, systemic humoral immune response in different strains of mice. The antibody response was enhanced as the dose of oil was increased and the particle size of emulsions was decreased. Feeding of aqueous β-Lg could induce the antibody response only when emulsified oil was fed almost simultaneously. However, the emulsion-driven humoral immune response was not observed when mice were treated with anti-CD40 ligand antibody or in athymic mice. It is likely that the intestinal coexistence of emulsified oil with dietary antigens modulates the immune system to crucially support B cell response. A practical application of the present results to the prevention of cow's milk protein sensitization is infants proposed.

  • ヌクレオチドの経口摂取が、腸管上皮間リンパ球(IEL)のTCRγδ陽性細胞の割合および腸管上皮細胞(IEC)のIL-7産生を高める。つまり、ヌクレオチドの摂取はIELとIECの細胞分子上の相互作用を修飾する。(2000)
    発表者

    Sinya Nagafuchi, Mamoru Totsuka, Satoshi Hachimura, Masao Goto, Takeshi Takahashi, Takaji Yajima, Tamotsu Kuwata, Shuichi Kaminogawa

    雑誌名

    Bioscience Biotechnology Biochemistry 64(7)1459-1465(2000)

    要約

    Dietary Nucleotides Increase the Proportion of a TCRγδ+Subset of Intraepithelial Lymphocytes (IEL) and IL-7 Production by Intestinal Epithelial Cells (IEC); Implications for Modification of Cellular and Molecular Cross-talk between IEL and IEC by Dietary Nucleotides

  • ヌクレオチドの経口摂取は、マウスの抗原特異的なTh1免疫応答を促進し、抗原特異的なIgE産生を抑制する(2000)
    発表者

    Sinya Nagafuchi, Satoshi Hachimura, Mamoru Totsuka, Takeshi Takahashi, Masao Goto, Takaji Yajima, Tamotsu Kuwata, Sonoko Habu, Shuichi Kaminogawa

    雑誌名

    International Archives of Allergy and Immunology 122,33-41(2000)
    (出版元S.kargerAG,Basel)

    要約

    Dietary Nucleotides Can Up-Regulate Antigen-Specific Th1 Immune Responses and Suppress Antigen-Specific IgE Responses in Mice


    ヌクレオチドの経口摂取は、マウスの抗原特異的なTh1免疫応答を促進し、抗原特異的なIgE産生を抑制する (要旨)

    Dietary Nucleotides Can Up-Regulate Antigen-Specific Th1 Immune Responses and Suppress Antigen-Specific IgE Responses in Mice Sinya Nagafuchi, Satoshi Hachimura, Mamoru Totsuka, Takeshi Takahashi, Masao Goto, Takaji Yajima, Tamotsu Kuwata, Sonoko Habu, Shuichi Kaminogawa International Archives of Allergy and Immunology 122,33-41(2000) (出版元 S.kargerAG,Basel)

    要旨

    Abstract

    Background: It has been reported that dietary nucleotides enhance T helper cell activities. In this study, we have determined the effects of dietary nucleotides on antigen-specific Th1 and Th2 responses and IgE responses. Methods: Ovalbumin (OVA) -specific T cell receptor (TCR) transgenic (OVA-TCR Tg) mice, 3 weeks old, were fed a nucleotide-free diet (NT(-) diet) or the NT(-) diet supplemented with dietary nucleotides (NT(+) diet) for 4 weeks. Cytokine production by spleen cells and macrophages obtained from these mice was measured in vitro. BALB/c mice, 3 weeks old, immunized intraperitoneally with OVA adsorbed onto alum, were fed the NT(-) diet or the NT(+) diet for 4 weeks. Serum levels of antigen-specific antibodies in the BALB/c mice were determined by ELISA. Results: The level of production of antigen-specific interferon-γ by spleen cells was significantly higher in the OVA-TCR Tg mice fed the NT(+) diet than in the control mice. The levels of secretion of bioactive IL-12 by spleen cells and peritoneal macrophages were also significantly increased in the NT(+) diet group. The serum OVA-specific IgE level was significantly decreased in BALB/c mice fed the NT(+) diet compared with those fed the NT(-) diet. Conclusion: These results show that dietary nucleotides up-regulate the antigen-specific Th1 immune response through the enhancement of IL-12 production and suppress the antigen-specific IgE response.

  • たん白質栄養から見た乳児用調製粉乳における母乳化の展望(2000)
    発表者

    金子哲夫

    雑誌名

    日本臨床栄養学会雑誌21(3, 4)13-17(2000)

論文一覧

乳酸菌に関する研究

食品・食品素材に関する研究

栄養に関する研究

技術研究