Findings from 1073R-1 lactic acid bacteria research(1)

Yogurt containing 1073R-1 lactic acid bacteria has been confirmed to reduce the risk of catching the common cold and enhance NK activity (human study conducted in seniors from 2005 to 2007).

A study was conducted in 57 healthy seniors (69–80 years old) living in Funagatamachi, Yamagata Prefecture, and 85 healthy seniors (59–84 years old) living in Aritacho, Saga Prefecture, in order to investigate the effects of lactic acid bacteria on the immune system. Each of these regional subject pools was divided into two groups. One group consumed 90 g of yogurt containing 1073R-1 lactic acid bacteria per day. The other group consumed 100 ml of milk per day. The subjects in Funagatamachi and Aritacho were kept on this dietary regimen for 8 and 12 weeks, respectively, then changes in their physical conditions and immunity were compared. For both regions, the groups consuming yogurt containing 1073R-1 lactic acid bacteria had a significant*1 increase in the ability to produce T cells, which tends to decline with age. Furthermore, in the groups consuming the yogurt in both regions, subjects with low NK activity before the consumption experienced a significant increase in NK activity. In addition, the risk of catching the common cold was reduced in the yogurt-consuming groups. If the risk of catching the common cold in the milk-consuming group is 1, the risks in the groups consuming yogurt containing 1073R-1 lactic acid bacteria in Aritacho and in Funagatamachi were 0.44 and 0.29, respectively. With these two risks combined for analysis, the weighted average risk is 0.39, indicating a significant reduction in the risk of catching the common cold.
In addition, when adaptive immunity was evaluated in Aritacho, it was confirmed that T cells, which serve to suppress the activities of specific viruses and bacteria, were activated by the consumption of the yogurt.

*This means that the experiment was statistically proven to be effective. As it is common to apply p＜0.05 as the level of significance (i.e., less than 5% chance of sampling data 100 times and finding different results), this level was used in this study.

A human-subject study verifies the efficacy of 1073R-1 lactic acid bacteria in reducing the risk of cold infection

Yogurt containing 1073R-1 lactic acid bacteria enhanced NK activity and reduced the risk of catching the common cold.

*Meta-analysis was performed by the Mantel-Haenszel method after consolidating study data from Aritacho and Funagatamachi.
*Analysis of the study data collected in Aritacho and Funagatamachi was performed by Fisher’s test.

Result of the study conducted on NK activity in Funagatamachi, Yamagata Prefecture

Subject pool	Healthy seniors aged between 69 and 80 living in Funagatamachi, Yamagata Prefecture
Number of subjects	Group that was fed milk: 28 Group consuming yogurt containing 1073R-1 lactic acid bacteria: 29 subjects
Amount	Milk: 100ml/day Yogurt containing 1073R-1 lactic acid bacteria: 90g/day
Period of consumption	Ingestion for 8 weeks
Study period	March to May 2005

Result of the study conducted on NK activity in Aritacho, Saga Prefecture

Subject pool	Healthy seniors aged between 59 and 84 living in Aritacho, Saga Prefecture
Number of subjects	Number of subjects 42 Group consuming yogurt containing 1073R-1 lactic acid bacteria: 43 subjects
Amount	Milk: 100ml/day Yogurt containing 1073R-1 lactic acid bacteria: 90g/day
Period of consumption	Ingestion for 12 weeks
Study period	November 2006 to February 2007

(Source: Makino S, et al. Br J Nutr. 2010;104(7):998-1006.)