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What is the immune system? Relationship between lactic acid bacteria and people’s immune strength Function of NK cells Findings from 1073R-1 lactic acid bacteria research

Findings from 1073R-1 lactic acid bacteria research(3)

Yogurt containing 1073R-1 lactic acid bacteria has been confirmed to potentially reduce the risk of influenza infection (animal study conducted in 2011).

In a joint research project with Kitasato University, we conducted a study that involved infecting mice with influenza A (H1N1) virus. One group of mice was fed with yogurt containing 1073R-1 lactic acid bacteria while the other group was fed with water from 21 days before the infection until four days after it, and the two groups were compared.

The results indicated that feeding mice with yogurt containing 1073R-1 lactic acid bacteria beforehand improved their survival rate after the infection.

Whereas the mice in the control group that were only fed water all died within 10 days of the viral infection, the yogurt-fed mice’s survival rate continued to improve even after infection, while their lifespans also became longer.

Ingestion of 1073R-1 lactic acid bacteria improves the survival rate of mice infected with influenza viruses

1073R-1 lactic acid bacteria improves survival rates and lifespans!

Decrease in infectious viral titers

The graph below indicates the result of a study that measured infectious viral titers (i.e., number of infectious viruses), which is an indicator of influenza virus propagation.
Four days after infection with the influenza virus, the infectious viral titers in the lungs of mice fed with yogurt (0.4 ml/day) and fed with water were compared. The viral titer among the yogurt-fed mice apparently decreased compared to the water-fed mice.
Furthermore, when the spleen cells of mice (i.e., cell population consisting of various immune cells) were examined after the infection, it was confirmed that NK cells, which are responsible for natural immunity, were activated, exhibiting anti-influenza virus activity.

Study
method
Animal study
Administration The subject pool was divided into the following two groups:
1. Water
2. Yogurt containing 1073R-1 lactic acid bacteria
Period of administration 4 weeks
Study
period
2011

(Source: Nagai T, et al. Int Immunopharmacol.2011;11(12):2246-50.)